To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses.
Our earlier study revealed that STRA6 (stimulated by retinoic acid gene 6) was up-regulated within 3 h of TCR stimulation.STRA6 is the high-affinity receptor for plasma retinol-binding protein (RBP) and mediates cellular vitamin A uptake.We generated STRA6 knockout (KO) mice to assess whether such up-regulation was critical for T-cell activation, d